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KMID : 0378019860290120115
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New Medical Journal
1986 Volume.29 No. 12 p.115 ~ p.130
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The Effects of Caffeine and Acetylsalicylic Acid on Spinal Flexor Reflex Induced by Algesic Substance in Cat
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Abstract
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The present study was done in order to investigate the effects of psychotropic drug, caffeine and the most frequently used drug as an analgesics, Acetylsalicylic acid (ASA) on the spinal flexor reflex induced by potassium chloride (KCI) After injection of caffeine only or ASA and caffeine combined into the gastrocnemius-soleus muscle through the sural artery, KCI injected into the same site with regular time interval. Impulse discharges from the spinal motoneurons were recorded in the alpha and gamma motor axon extracellularly.
The obtained results and conclusions are summarized as follows:
1. In case that 5mg of caffeine were injected into the gastrocnemius-soleus muscle. through the sural artery, and subsequently KCl was injected into the same artery with 3min. intervals, the frequency of impulse discharge and the duration of response from spinal flexor alpha-motoneurons were increased more when the caffeine was injected than it was not. But the latancy of response was diminished.
2. In case that 5mg of caffeine were injected into the gastrocnemius-soleus muscle through the sural artery, and subsequently KCl was injected into the same artery with 3min. intervals, the frequency of impulse discharge and the duration of response from spinal flexor gamma-motoneurons were increased more when the caffeine was injected than it was not. But the latency of response was diminished.
3. In case that 5mg of ASA and 5mg of caffeine were injected, and then KCl was injected with 3min. intervals, the frequency of impulse discharge, the duration and the latency of response from spinal flexor alpha-motoneurons were momentarily increased for several minutes, but the rate of these were less increased than when the caffeine only was independently injected.
4. In case that 5mg of ASA and 5mg of caffeine were injected, and then KCl was injected with 3 min. intervals, the frequency of impulse discharge the duration and the latency of response from spinal flexor gamma-motoneurons were momentarily increased, but soon these became normal. Also these were less increased than when the caffeine only was independently injected.
5. In case that the mixture of 5mg of ASA and 5mg of caffeine were injected, and then KCI was injected with 3 min. intervals. The frequency of impulse discharge from unmyelinated fiber of spinal dosal root nerve fiber was remarkably decreased. Also, the duration of response was decreased. But the latency of response was increased. To summarize the above results, it suggests that caffeine has activated the spinal motoneurons and when ASA and caffeine treated simultaneously, caffeine dtsinhibited the inhibitory effects of ASA on spinal flexor reflex and consequently it suggests that ASA couldn´t strong inhibitors for the caffeine that activated spinal flexor reflex.
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